The Role of Angiotensinogen rs699 in Diabetic Nephropathy Among Type 2 Diabetes Mellitus Patients with Uncontrolled Postprandial Glucose Levels

Diabetic Nephropathy (DN) is the most common complication of Type 2 Diabetes Mellitus (T2DM), leading to highest mortality rate DM complications. However, its etiology still questionable. Hyperglycemia, hypertension, and particular genetic susceptibility are associated with DN. Not all patients uncontrolled hyperglycemia suffer Thus, may be a risk factor for The variant angiotensinogen rs699 known DN inconsistent results between ethnicities. This study aims reveal correlation AGT incidence diabetic nephropathy among type-2 diabetes mellitus postprandial glucose levels in Jambi Malay ethnicity. was observational analytic research cross-sectional design. It used 48 DNA samples from levels. authors took 24 without (as control group). genotyping method ARMS-PCR specific rs699. Subjects CT genotype had lower than CC genotype, but it not statistically significant (p=0.247; OR=0.508; 95%CI=0.160-1.607). In addition, subjects T allele (p=0.331; OR=0.621; 95%CI-0.237-1.630) C allele, significant. conclusion, Angiotensinogen